Abstract
The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against two human carcinoma cell lines. These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cyclin-Dependent Kinases / antagonists & inhibitors*
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Cyclin-Dependent Kinases / metabolism
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Growth Inhibitors / chemical synthesis
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Growth Inhibitors / pharmacology
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Humans
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Indoles / chemical synthesis*
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Indoles / pharmacology
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Protein Kinase Inhibitors / chemical synthesis*
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Protein Kinase Inhibitors / pharmacology
Substances
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Antineoplastic Agents
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Growth Inhibitors
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Indoles
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Protein Kinase Inhibitors
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Cyclin-Dependent Kinases